The Titans can't stop the pass, are missing their best pass rusher, Denico Autry, and have a cluster injury problem in their secondary. The Chargers can't stop the run and are missing key defensive backfield players. 

So this sets up as a higher scoring game than the oddsmaker anticipates. 

Derrick Henry entered this week ranked No. 2 in rushing. The Chargers are 28th in run defense and 28th in scoring defense. They are likely to be without star safety Derwin James and cornerback Bryce Callahan again this week. Henry should find success running, which in turn will aid Ryan Tannehill in the Titans' passing game. 

Mike Williams returned for the Chargers last week after missing two games with an ankle injury. That makes a huge difference in LA's passing attack. Williams is the Chargers' lone deep threat. He opens up the attack for Justin Herbert. 

Herbert is in line for a monster performance operating against a Titans secondary that ranks last in the NFL. 

The Chargers have been an elite kicking team this season unlike past years. LA kickers are 25-for-27 in field goals and 30-for-30 in extra points.