20* San Francisco 49ers
Today I am taking San Francisco as road underdogs against the Indianapolis Colts. SF is the much better team here as currently constructed. I understand they are 0-4 but could so very easily be 3-1 as they lost to Seattle, LA, and Arizona by a total of 8 points combined. They have been very competitive and will get their first win of the season this afternoon. I expect Carlos Hyde to have a big game and for the 49ers to establish the run and win up front in the trenches. Take SF to the bank!