Stephen Nover's NFL Sunday Spread Crusher
(NFL) Arizona vs. Cleveland, 10/17/2021 4:05 PM, Score: 37 - 14
Point Spread: -2.50 | -122.00 Cleveland (Home)
Result: Loss
The Cardinals are the NFL's lone unbeaten team. By the time this game finishes, I highly doubt Arizona still will be without a loss.

This game sets up well for the Browns. Cleveland easily is the No. 1 rushing team in the NFL thanks to Nick Chubb and Kareem Hunt. The Cardinals rank 28th in run defense. 

Kyler Muray has been carrying the one-dimensional Cardinals. He's bothered by a shoulder injury in his passing arm and is likely to be without his injured center Rodney Hudson. Early reports are the Browns will have a number of their banged-up defensive players available for this game. 

The warm-weather Cardinals are traveling into heavy wind.