Stephen Nover's NFL Underdog Big Casher - 10-5 Underdog Run
(NFL) San Francisco vs. Jacksonville, 11/21/2021 1:00 PM, Score: 30 - 10
Point Spread: 6.50 | -102.00 Jacksonville (Home)
Result: Loss
The 49ers are off one of the most impressive victories of the season. They beat the Rams, 31-10, at home this past Monday night. 

But the 49ers are a below .500 team. They have a banged-up secondary, an overrated coach and a mediocre quarterback. They just aren't that good. It's a horrible spot for them traveling cross-country on a short week while basking in the glow of a huge upset division victory. It's also an early start time for San Francisco. 

Jacksonville is below-the-radar. The Jaguars' defense has gotten better. They've surrendered an average of 20 points in their past four games. 
The Jaguars stunned the Bills at home two weeks ago and hung tough staying within one score of the Colts on the road this past week. 

The 49ers are run-oriented. They use the run to set up Jimmy Garoppolo. The Jaguars' strength is their 12th-ranked run defense. Garoppolo and the 49ers can and should not be trusted in this spot against this improved foe that is 2-2 SU, 3-1 ATS in its last four games.