Timing is very bad for the Saints here. This is a short week for the Saints. They've been without their best offensive players - Alvin Karmara, Jameis Winston, Michael Thomas and tackles Terron Armstead and Ryan Ramczyk. These injuries have turned the Saints into a punchless, weapon-less offense operated by Trevor Siemian, one of the more ineffective backup quarterbacks in the league.

The result is New Orleans is on a three-game losing streak. That hasn't happened to the Saints since the first three games of the 2016 season.

New Orleans draws a much more well-rounded - and angry Bills team that just got destroyed, 41-15, at home by the Colts this past Sunday. The Bills have followed up their previous three losses with blowout victories winning those next games by an average of 26 points.

Buffalo ranks No. 2 in scoring at 29.5 points and is fifth in total yards. The Saints can't keep up with that. Their offense is just a shell of its former self.

New Orleans' defensive strength is its run defense, although you couldn't tell by watching the Saints get trampled by the Eagles this past Sunday. The Bills, though, are a passing team. The Saints are giving up 29.2 points per game during their last four games. That's right on the number of what the Bills average per game.