Point Spread: -5.50 | -103.00 Las Vegas (Home)
The 49ers come into Arizona without their starting QB, and their star TE. They are sending rookie Trey Lance into the fire, and he doesn't look like he's ready to start in this league. He faces the only undefeated team in the NFL, with an MVP candidate at QB. The 49ers are 4-9 ATS in their last 13 games overall, and they have failed to cover in six of their last seven versus the Cardinals.