Point Spread: -3.50 | -115.00 San Francisco (Away)
San Francisco is coming off an impressive road win at New Orleans, ending a 14 game home win streak of the Saints. They got the running game going last week, racking up 144 yards and a pair of TDs. They should be looking at bigger numbers here in New York, facing a Giants defense that ranks dead last against the run, allowing opponents to average over 144 yards per game.
The Giants are coming off four straight losses, and they know there isn't a lot left to fight for this season. Injuries have taken their toll on this team, with Prince Amukamara the latest casualty in a decimated secondary. Victor Cruz is gone for the year, and RB Rashad Jenning has missed the last four games. He could come back this week, but it's not exactly a favorable matchup against a stout San Francisco defense.
The loss of Patrick Willis will hurt, but welcoming Aldon Smith back from suspension should soften the blow. San Francisco has had it's fair share of injuries on defense this year, but it hasn't stopped them from remaining among the NFL's elite. The Niners rank 5th overall against the run, and 7th against the pass. They have 11 interceptions, just three fewer than Arizona who lead the league with 14.
The Giants have lost four straight by double digits, and there's not a lot of reason to expect a better result this week.