Monday Night Football lines are usually tight, but I will back Pittsburgh here. Daniel Jones is 1-14 in prime-time games in his career, with nine of those losses coming by seven points or more. The Steelers are the second best in the NFL in scoring defense, allowing 14.4 ppg, and the Giants are the 31st scoring offense, averaging 14.1 ppg. This may seem like a big spread, but all five of Pittsburgh's outright wins have come by at least seven points or more.
I will lay the points with Pittsburgh, expecting a win in the 21-13 range.

1.5% play on Pittsburgh