Point Spread: 9.50 | -125.00 Miami (Away)
Honestly, I think that Ryan Fitzpatrick and the Dolphins have a legitimate shot at winning this one outright. The 49ers are coming off a 25-20 home loss to the lowly Eagles as 5-point favorites. The 49ers are without starting QB Jimmy Garapolo and many other starters on both sides of the ball. San Fran will have to contend with a decent Miami defense as well, which is ranked 14th overall. I can't see San Fran running up this score if it has the lead in the second half, so that definitely favors Miami with this huge spread, which will be keeping the foot on the gas from start to finish. Grab the points!
T.M. Prediction: 24-23 Miami.