(NFL) San Francisco vs. Arizona, 10/10/2021 4:25 PM, Score: 10 - 17
Point Spread: 5.50 | -110.00 San Francisco (Away)
Result: Loss
This is an 8* SPECIAL on the 49ers.

I like the 2-2 San Francisco 49ers to, at the very least, take this one right down to the wire.

The Cardinals are 4-0.

Dating to last year though the 49ers have won three straight on the road. Jimmy Garoppolo has 925 passing yards, five TD's and two INT's.

The 49ers ground game has been strong so far, averaging 120.2 YPG.

San Francisco's weakness to this point has been on the defensive end, the enter allowing 24.3 PPG.

Dating to last season the Cards have split their last eight home games. QB Kyler Murray has 1,273 passing yards, nine TD's and four INT's. Arizona also has a strong run game that averages 147.8 YPG.

But like their opponent today, the Cardinals' defense has for sure been Arizona's weak point, as the unit concedes 23.5 PPG.

Despite their 2-2 record the 49ers have done well in this position for bettors, going 4-1 ATS in their last five vs. the division.

The Cardinals on the other hand are just 1-5 ATS their last six at home.

San Francisco's two wins this season have come on the road. I'm not calling for an outright upset here, but I do think it'll be decided in the final moments.

Grab the points, the play is SAN FRANCISCO.

Good luck, NP