First meeting between these division rivals and I'm not taking Duke to cover such a big spread, regardless of how bad Louisville has been. Duke has only covered 1 spread this large vs a conference foe and the times they should've covered the spread the have fallen short vs much worse opponents than Louisville. I do expect Duke to win by 10+ but not 18-20 points. Louisville has record of themselves covering large spreads vs the likes of Miami and UVA.

Official Play: Louisville +18.5

Side Bet: Over 137.50