The 49ers are coming into this game with a 2-3 record this season and this is a very big game for them to get back in the NFC West race. A win in this game puts them back at the top of the division with the Seahawks at 3-3, and the 49ers already have 2 division losses this season so this is an important game for them. They are going up against a Seahawks team that is 3-2 this season and has now lost 2 straight games. They are coming off of a 29-20 loss against the Giants at home in their last game and their defense has been awful recently, allowing 71 points total in their last 2 games. Their defense has had a big problem stopping the run this season and the 49ers have a very good run game with Jordan Mason taking over for injured McCaffrey. They have not been defending the pass well either as they allowed Daniel Jones to go 23/34 for 257 yards and 2 TDs in their last game and allowed Goff to shred them the game before as well. The 49ers have struggled on defense this season but they have a lot of quality pieces on their defense and they will step up for this game after blowing late leads in both of their divisional games. Both teams have great weapons on offense but the Seahawks defense is going to struggle to stop the run here which will open up the passing game for the 49ers. The 49ers have also struggled to stop the run, but they have the better pieces on their defense to step up and stop this offense and that will be the difference here as the 49ers have also won their last 5 straight games against the Seahawks, including the last 2 in Seattle by 7+ points in each. The 49ers will cover the spread in this game.