Detroit will have one mission in this game, and that is, can they stop the 49’s run game. They will need to create turnovers in which San Francisco gives up very little of. This game is outdoors in the elements, despite the weather being good and Goff does not have a good road record when out of the dome. Their team has averaged 17 points in offense per game in open air stadiums when on the road this season. Goff is 0-5 SU versus San Francisco lifetime. Also, the Lion’s pass defense is giving up way too many passing yards which will be a problem as they struggle to stop the pass. The Lions have given up more points to the opposing team while playing on the road this season. If Detroit gets behind early, they have shown they struggle to come back from behind as well. On the flip side, San Francisco had their near miss and scare game, so they have shaken the rust off and will be mad about their performance and angry going forward. The only question SF needs to answer is if Debo will play or not. As of this posting, he is scheduled to play so the 49’s will have all their key pieces. If he does not, Purdy has also shown that he can come from behind and not lose his composure as he did versus Green Bay even after Debo went out of the game. That will help carry this team forward with that confidence. Kittle should have a big game as they will use him more, and of course McCaffrey will be their best weapon. This team will be unstoppable, even against the Lions as experience, talent and coaching will make the difference in this game.

Best bet: lay the points with San Francisco.