The 49ers return one of the NFL's best defenses even without Bosa likely available for a long stretch after signing this week and ending his holdout. Brock Purdy returns for his second season and has a full complement of offensive weapons at his disposal. Steelers quarterback Pickett has had a good camp but will have trouble against the Niners pass rush on Sunday. I also favor the offensive schemes of Shanahan against the Steelers' defense. Take the 49ers -2.5