The Cardinals have allowed Carson Palmer to be sacked 11 times, the fourth-highest total in the NFL. Palmer could have more trouble now that the left side of his offensive line has been ruled out as neither left tackle Mike Iupati nor left guard Alex Boone will play. Boone is out with a pectoral injury while Iupati was put on IR. Palmer is past his prime and doesn't have his security blanket, David Johnson. The absence of Johnson greatly weakens not only the Cardinals' ground attack, but also its passing. Johnson is the best pass catching starting running back in football. Arizona's receiving corps is banged-up, too, as neither John Brown nor JJ. Nelson are 100 percent. The 49ers got their offense going against the Rams scoring 39 points while finally showing a grasp of Kyle Shanahan's new offense. The 49ers' defense is improved from last year and better than it showed against the Rams, who are the most improved offensive team in the league. The 49ers have had extra rest and practice time having last played a week ago Thursday. The Cardinals, on the other hand, are on a short week having played this past Monday night. The Cardinals haven't been very good at home either failing to cover 12 of their last 18 home games.