There's nothing wrong with a highly talented Broncos defense that a decent quarterback can't cure. A seismic climate change from a combination of Brock Osweiler/Trevor Siemian to Case Keenum should prove a winning elixir especially in this spot for Denver.
Given weapons and a dominant defense, Keenum led Minnesota to 13 wins in its last 15 games before a loss to the Eagles in the NFC title game. Denver has the pass rushers with Bradley Chubb joining Von Miller to make things rough on Russell Wilson, who may be without his top receiving weapon if Doug Baldwin isn't able to play because of a knee injury that kept him out of preseason.

Wilson is a one-man band. Seattle has huge weaknesses in the offensive line, tight end and wide receiving depth. The Seahawks no longer have their fabled Legion of Boom defense to fall back on either due to defections and the retirement of safety Kam Chancellor.

The Broncos have opened at home each of the last six years. Their record in these games is 6-0 SU, 4-1-1 ATS. Opponents aren't conditioned yet to play 60 minutes because of spot playing their starters during preseason. This situation is made worse for Denver's foes because of playing in high mountain altitude that increases their fatigue factor.

Even under normal conditions and when their defense was much better, the Seahawks still encountered road problems early in the season going 0-6 SU and ATS the past four years in away games played during the first three weeks.