I don't want to minimize Portland not having Damian Lillard here. It's a big loss. But Detroit has nothing anymore. The Pistons have gotten rid of Andre Drummond, Reggie Jackson and Markieff Morris. 
The Pistons have lost five in a row. I can't see them being competitive on the road against a borderline Western Conference playoff team that has motivation. The Trail Blazers can't afford to take the Pistons lightly. And they won't minus Lillard and being 3 1/2 games back of the final playoff spot in the West. 
Even minus Lillard, the Trail Blazers still have the three best players on the court in CJ McCollum, Hassan Whiteside and Carmelo Anthony. 
Portland is a top-eight scoring team that averages nearly 114 points. Detroit has no firepower anymore. The Pistons are averaging 96.6 points during regulation in their last five games.