We know this about the Twins: They are coming off a 101-win season and a major league record 307 homers. 
We know this about the White Sox: They have some intriguing young talent and are projected to challenge for the AL Central Division title. But they are untested. 
The Twins are the proven commodity. The White Sox are unknown. I like Twins starter Jose Berrios more than White Sox starter Lucas Giolito in this matchup. The price is right to back Minnesota. 
The Twins dominated the White Sox last season winning 13 of 19 times. Minnesota scored 231 more runs than Chicago last year. 
Berrios has a strong history versus the White Sox with an 11-2 record and 2.40 ERA in 14 career starts. This includes a 4-1 mark and 2.88 ERA against the White Sox last season. 
By contrast, Giolito is 4-5 with a 4.58 ERA in 10 career starts versus the Twins.