Indy ranks first defensively. But I'm not buying that the Colts have the best defense, especially if they are missing their top defensive player, injured linebacker Darius Leonard. I'm not expecting Leonard to play Sunday due to a groin injury. 
The Colts have faced the Jaguars, Vikings, Jets and Bears. The Browns are the most balanced offense they've gone against. 
The Browns have produced 34 or more points each of the last three weeks. Kareem Hunt is a capable bellcow running back with Nick Chubb injured. Baker Mayfield is in a better system with better coaching. Odell Beckham Jr. is flashing his immense talents again. 
Indy can't match Cleveland's firepower. The Browns have held their opponents to 3.5 yard per rush, which ranks fifth-best. The Browns lead the NFL with 11 takeaways. Their banged-up secondary is getting healthier. So this is a tough matchup for a conservative Colts offense that relies on rookie RB Jonathan Taylor and over-the-hill Philip Rivers to play game-manager.