Loyola's always a nice NCAA Tourney story. But the Ramblers aren't nearly in Illinois' class. Yes the point spread reflects that, but not to the full degree.
Just how good is Illinois? The Illini very well could be the second-best team in the nation next to Gonzaga. 
The Illini are playing at this high level going 15-1 SU, 12-4 ATS in their last 16 games. The combination of Kofi Cockburn and Ayo Dosunmu are too much for Loyola to keep this within single digits. 
Illinois has done this against major competition, too. The Illini are 15-5-1 ATS in their last 21 games versus above .500 foes. 
Loyola hasn't been good when getting points failing to cover eight of the last 11 times in that role.