Toronto isn't going to be very good this season. The Raptors are especially lower tier without Pascal Siakam, who is their main offensive weapon. 
Indiana is the better team. The Pacers hold a frontcourt edge with Domantis Sabonis and shot-blocker supreme Myles Turner. Rookie Chris Duarte is off to a hot start and Malcolm Brogdon is one of the most underrated players in the NBA. 

Fred VanVleet is the Raptors' main cog with Siakam out. VanVleet is turnover-prone and shoots a very low percentage from the floor. I like Brogdon to handle him. 

The Pacers are stepping down in class after defeating the Heat this past Saturday and hanging tough in a loss to the defending champion Bucks two days ago. 

The Raptors are 0-3 at home. They've lost to the Wizards, Mavericks and Bulls by an average of 8.6 points a game. Toronto is 0-7-1 ATS in its last eight home contests going back to last season. The Pacers have been excellent in this situation going 19-6-2 ATS in their last 27 road games versus opponents with a losing home mark.