I have no doubt the Colts will be up for this game. They have to be sitting 0-2. But Indy can't compete offensively with the Chiefs. 

Patrick Mahomes lost Tyreek Hill. But this loss has been more than offset with better receiving depth both at wide receiver and at running back along with an improved offensive line. Gus Bradley is the Colts' new defensive coordinator. He's an overrated defensive coordinator, whose style is a conservative Cover 3 defense. Mahomes picks apart this style of coverage. He's thrown for 966 yards with a 9-to-0 touchdown-to-interception ratio the past three times he's gone against a Bradley defense. 

Matt Ryan can't keep up with this. Ryan isn't Tom Brady. He's an old 37. Aside from Jonathan Taylor, Ryan has limited weaponry. He's looked terrible so far. Ryan's been sacked seven times, thrown four interceptions and fumbled five times in his two starts with Indy. 

The Chiefs are on an extra rest, too, having played their Week 2 game on a Thursday. Andy Reid is one of the best coaches with extra prep time.