The Buffalo Bills will be in Cleveland on Thursday night, playing their second pre-season game against the Browns. Buffalo has already suffered a big blow losing LeSean McCoy to an injury, and Rex Ryan is even considering bringing in Ray Rice. The Browns are coming off a home loss to Washington in the first week of exhibition, so they should be eager to get a positive result here at home tonight.

Here are my keys to the game:

1. Quarterbacks - Neither team has a bonafide stater, as Johnny Manziel, Josh McCown and Thad Lewis are battling for spots in Cleveland, and E.J. Manuel and Matt Cassel appear to be the best candidates to win the job in Buffalo.

2. Ground & Pound - The Bills ran the ball 45 times for over 200 yards in Week 1, attempting just 27 passes. The Browns had 37 running plays compared to just 28 pass attempts.

3. X-Factor - The under is 13-3 in Bills last 16 games overall, while Cleveland has gone under in nine straight versus the AFC.

Selection: This is a play on BUF@CLE to go UNDER the total (10*)