At 4:05pm ET, my NFC West Game Of the Year is on Arizona. The 49ers are a strong team but they will have their hands full with the Cardinals on Sunday. At 1-3, Arizona is coming in desperate. The Cardinals could have a better record and have played pretty well in 3 of 4 games. Their only road game was a 6-point loss at Buffalo and they very nearly won that game. The 49ers earned a big victory last week. That was against a New England team which isn't very good. This divisional opponent has a lot more teeth and comes in needing and expecting to win. The 49ers have a plethora of injuries. Key players Fred Warner and George Kittle both missed Wednesday practice. Whether or not they play remains to be seen but either way this team is not healthy. Before the win over New England, the 49ers were off consecutive losses. Things aren't all better yet and they will get surprised by their upset-minded guests. Grab the points.