Buffalo very thin at all positions, especially at LB as Reggie Ragland likely out. Bills will rest RB/KR Reggie Bush. Starting receiver Sammy Watkins is out for Bills. Colts star QB Andrew Luck will play. Last year was hampered by injuries and poor play many believe the result of playing hurt. Luck himself admitted he was a bit more fired up for a preseason opener. So I expect him to be as motivated as any star QB would be in week 1.

But most importantly, the lack of depth of Buffalo will be an issue.