Arizona will unleash Murray for the first time this season after he sat out the entire preseason. He has a good receiving group this year, featuring rookie wideout Harrison Jr. The Bills offense will look different this year without their two primary WRs from last season but they still have QB Allen, a solid ground game, and two solid TEs. The Bills can control tempo this season with a slower-paced offense and Allen will once again be the focal point.
Take the Bills -6.5