San Francisco is just 1-3 at Seattle in their last five appearances and haven't won there since 2019. Rookie QB Purdy will face his first road test of the season and this one is a doozy in the record-setting noise levels of Seattle. Samuels' absence will hurt the 49ers ability to get rid of the ball quickly and make plays. RB Walker IV is back for this game which will help the Seahawks in a must-win game for Seattle. Take Seattle with the points.