Recent Performance: The 49ers are finding their rhythm again after a close 23-20 victory over Tampa Bay, showing resilience and improved form. On the flip side, the Seahawks are in a slump, losing five of their last six games, highlighting significant struggles on both sides of the ball.

Head-to-Head Advantage: San Francisco has already proven their dominance over Seattle this season with a convincing 36-24 road victory, showcasing their ability to exploit the Seahawks’ weaknesses. This strong matchup advantage favors the 49ers at home.

Home Field Edge: The 49ers are a solid 3-2 against the spread (ATS) at home, while the Seahawks have had difficulty performing on the road, adding another layer of advantage for San Francisco in this spot.

Offensive Firepower: The 49ers boast a dynamic offense led by QB Brock Purdy, who threw for 353 yards and two touchdowns in his last outing. With weapons like Jordan Mason, George Kittle, and Deebo Samuel, San Francisco has the firepower to exploit Seattle’s defensive vulnerabilities.

Defensive Dominance: San Francisco’s defense is a mismatch for Seattle’s offense. The 49ers have allowed an opposing passer rating of just 29.9 under pressure since Week 7, ranking 3rd-best in the NFL. This spells trouble for Seattle’s offense, which has struggled with consistency and protecting the quarterback.

First-Down Efficiency: The 49ers are a nightmare for opposing defenses on first downs, averaging 10.9 yards per attempt, the best in the NFL. Seattle’s defense, meanwhile, ranks among the worst in this category, allowing 9.1 yards per dropback, making it hard for them to keep pace.

The 49ers have the edge in recent form, head-to-head success, and both offensive and defensive matchups. San Francisco’s ability to dominate first downs and apply pressure defensively makes them the stronger side. Lay the points with the 49ers and expect them to continue their dominance over Seattle.