The 49ers have a six-game winning streak against Seattle. Every victory was by at least eight points and San Fran went 5-1-0 ATS in that span. It includes a 36-24 win in Seattle this season without Christian McCaffrey playing. The Seahawks have lost five of their last six games straight up and ATS. On both sides of the ball, San Francisco should dominate the run game again. The Niners should also win in sacks and turnovers. Expect the 49ers to pummel the Seahawks again.