The 49ers and Jimmy Garoppolo step way down in class here after opening against the Vikings in Minnesota last week. The 49ers still could have pulled the upset if not self-destructing deep inside Minnesota territory. Now they face a far easier defense and an offense that remains one-dimensional. Garoppolo has lost just once in eight NFL starts.

The spot sets up well, too, for the 49ers. The Lions last played in California opening week of 2015. They are making the long journey on a short week following their Monday home game against the Jets. Detroit will be on an off-surface, too, playing outdoors on grass instead of indoors on carpet.

The 49ers have owned the Lions at home. The last time they lost to Detroit at home was 1975, a string of 12 victories in a row.

San Francisco's held five of its last eight home opponents to 18 points or fewer last season.