I'm not convinced Penn State is the better team in this matchup even though Seton Hall is off to a slow start.
The Nittany Lions had an easy win against overmatched VMI in their opener and then nipped VCU, 72-69, this past Wednesday on a 3-pointer at the buzzer. Penn State failed to cover, though. So going back to last season, the Nittany Lions are 1-7 ATS in their last eight games. 
Seton Hall is 1-3 with a victory against Iona, but losses to Louisville by one point, to Rhode Island on the road and to 21st-ranked Oregon, 83-70, two days ago. The Ducks were blazing in that game hitting 53 percent of their shots from the floor. 
I envision the Pirates playing with a great deal of urgency. A straight-up victory by the Pirates would not surprise.