The Jaguars have had the Colts’ number over the years, even when they have appeared to be the inferior team coming in. Jacksonville is 6-1 ATS in their last seven games against the Colts, including four outright wins as an underdog over that period.
The Jags are favorites in the AFC South this season, coming off just their second division title since 2000. With the Colts led by rookie head coach Shane Steichen and rookie quarterback Anthony Richardson, I love the Jaguars in Week 1.