Major
(NBA) Toronto vs. Atlanta,
Point Spread: -2.50 | -110.00 Toronto (Away)
Result: Loss
Going with a rested road team against a home team in back-to-back and three games in four days is a very-long term winning percentage play.

The theory is that scheduling generally favors the home team. It is rare when the road team is more rested, but when it occurs, the scheduling dynamic means the home court advantage is less than usual.