Carolina at San Francisco 4:05 ET
Panthers (+) over 49ers- The two 'hottest' clubs in the NFC clash when the 49ers winners of five straight host the Panthers winners of their last four. This games pits two young quarterbacks in Carolina's Cam Newton and San Francisco's Colin Kaepernick who should lead these offenses that have dominated over the past month. The Panthers have won each their four games by 15 points or more while the Niners who rank last in the league in passing lead the NFL in rushing. The Panthers have a balanced attack that has used the same number of running and passing plays and they have a defense that has allowed only 13.3 points per game. Take CAROLINA!