This is too many points here in this one.
Houston is 3rd in the NFL in rushing yards per game (137.7), and Deshaun Watson has a Passer Rating of 118.3 with 12 TD and 2 interceptions since wideout Will Fuller returned to the lineup in Week 4. They've also scored touchdowns on 7 of their last 8 red zone drives.
Russell Wilson has been better on the road the road than at home. He only has 3 touchdowns against 2 interceptions at Qwest Field, compared to 8 touchdowns and only 1 pick away from home.

Take Houston plus the points to keep it close throughout.