The Seahawks have won just two games by more than six this year: a home rout of the Colts in Week 4 that they were losing at halftime, and a dismantling of a no-name Giants team off Seattle's bye. The 49ers almost pulled off a win in Seattle early in the season, and they've had two weeks to prepare for this game, coming off their BYE week. The Seahawks have a massive stretch ahead against the Eagles, Jaguars, Rams and Cowboys. They could get caught napping here and their defensive secondary and offensive line is banged up.
I like the home underdog with the SF 49ers.