Tampa Bay @ San Francisco 4:25 PM ET
Game# 123-124
Play On: San Francisco -3.0 (-120) (10*)

Forget about the San Francisco’s injury issues at quarterback. They will win this game by a comfortable margin with their stout defense and effectively running the ball on offense. The 49ers enter this week on a 5-games winning streak with all 5 wins coming by 6 points or more and 4 of those by 13 points or greater. Even further impressive is the fact that their defense has allowed 11.4 points per game during this current win streak. Speaking of the 49ers defense, they rank #1 in both points and yards allowed per game. San Francisco has held 8 of 12 opponents to less than 300 yards of total offense this season. On the other hand, Tampa Bay has scored 22 points or fewer in their last 8 and 10 of its previous 11 games.

NFL home favorites of 4.5 or less like San Francisco that are playing before Game 15 and they’re coming off home wins in their last 2 games, and they’re not undefeated, versus teams like Tampa Bay coming off a win and they have a win percentage of between .384 and .727, resulted in those home favorites of 4.5 or less going 11-0 SU&ATS since 1983. The average margin of victory came by 13.0 points per game.

Give me the 49ers minus the points.