The 49er's defense is excellent, and the 49er's offense is getting better as they adjust to having Jimmy G. back at QB and they are getting healthier. There are a couple of trends to see here. Namely, the 49ers are 9-1 against the spread in their last ten games after gaining 350 total yards or more in the previous game, and the Niners are 8-1 ATS in their final games against NFC foes. The Falcons are 5-0 against the spread this season. Statistically speaking that trend is highly unlikely to continue. The Falcons have been cashing cheap covers all year. That ends against a superior 49ers team. 49ers - 5 is the play.