(NFL) 49ers (SF) vs Bills (BUF)
(NFL) 49ers (SF) vs. Bills (BUF),
Point Spread: -6.00 | -112.00 Bills (BUF) (Home)
Result: Win
San Francisco still has injuries on defense with Nick Bosa out as well as others. Bills are third in scoring at 29.1 per game and seventh in points allowed at 19.5 per game. The 49ers were easily handled by Green Bay last week and Buffalo is much better than the Packers.