Seattle is far more experienced in big prime time game such as this and owns an eight-game win streak against the 49ers. The Seahawks are banged-up defensively, but are getting some of those players back, including Jadeveon Clowney. The 49ers also have key defensive injuries namely Kwon Alexander, Dee Ford and Jaquiski Tartt.
The Seahawks have won a staggering 84 percent of their prime time games under Pete Carroll, including beating the 49ers, 27-24, on the road in a Week 10 Monday night game.  
The Seahawks have a monster edge at quarterback in a matchup of Russell Wilson versus Jimmy Garoppolo. The Seahawks took care of their injury situation at running back by bringing back Marshawn Lynch. They also have an underrated running back in Travis Homer.