Iowa State is real down this season. Poor play on the road and the loss of star guard Tyrese Haliburton for the season are factors the Cyclonces can't overcome. 
The Cyclones are 0-8 SU, 2-6 ATS in true road games. In their last two road games, they lost by 29 at Oklahoma and by 15 at West Virginia. By comparison, Kansas just trounced Oklahoma by 17 points at home this past Saturday and two games ago defeated West Virginia on the road by nine points. 
That's a good current comparison showing the difference between Iowa State and Kansas and why I feel confident laying this many points with the Jayhawks. 
Kansas destroyed Iowa State, 79-53, on the road in the first meeting between the teams, too. 
The Jayhawks are 10-0 SU, 7-3 ATS since losing to Baylor. They trail the Bears by one game for first place in the Big 12 with six games left to play. So I'm not expecting a letup from Kansas especially after Iowa State beat Kansas in the Big 12 Conference Tournament last season.
If there's a letdown it probably would come from Iowa State as the Cyclones are coming off an 81-52 home win against Texas from Saturday.