Fresh off upsetting Pittsburgh, Washington has to travel on a short week and in a rare letdown spot. The 49ers also were in action on Monday, but have a far less journey.
 San Francisco also has more experience playing in Arizona. Playing there isn't so bad for the 49ers considering they were 1-4 at Levi's Stadium this season.   

The 49ers are far from full strength, but they are getting healthier each week. San Francisco is extremely well-coached on both sides of the ball and are very familiar with Alex Smith. 
Washington is likely to be without its best running back, Antonio Gibson. He's dealing with turf toe. 
This non-division game holds a lot of meaning to Kyle Shanahan. He and his father, Mike, were fired by Washington owners Daniel Synder. The 49ers shut out Washington, 9-0, last season and Kyle Shanahan awarded the game ball from that win to his father.