The set-up: Tom Brady is 28-3 all time against Buffalo and while he won't have offensive star TE Rob Gronkowski in the line-up, I still believe the all star will have more than enough to take care of the lowly (and injured) Bills.

The teams: After a 1-2 start the Pats come in having won four straight. Last week Brady threw for 277 yards and three TD's in the victory over the Bears. WR Josh Gordon had four catches for 100 yards. Sony Michel is also expected to sit this one out, so expect to see a heavy dose of James White.

The Bills are dealing with several injuries, including at QB. Buffalo is already planning ahead to next year and I believe it'll simply go through the motions tonight.

The pick: Take it for what you will as well but the Pats are 20-7 ATS in their last 27 after two or more consecutive victories, while Buffalo is just 10-13 ATS in its last 13 as an underdog. Lay the points and expect a rout.