The Buffalo Bills have already made themselves at home in the Big Apple after rallying from a 16-point deficit to open the season with a 17-16 road win over the NY Jets. I think they'll get the better over the NY Giants as well here in Week 2. The score may not reflect it, but Buffalo dominated the Jets on both sides of the ball as it outgained its opponent 358 to 203 in yards.

The Bills combined for four sacks in the victory and Giants QB Eli Manning could be in big trouble here against the Bills' elite pass rush. Manning completed only 30-of-44 passes and finished with a 22.4 QBR as the Giants took a 35-17 beating by Dallas last week.

The Giants are 1-6-1 ATS in their last eight home games and 2-8 ATS in their last 10 September games. The road team has covered the spread in five straight meetings, and Buffalo's superior defense should get the visitors the W in this matchup.

8* play on Buffalo Bills.