#475 ASA TOP PLAY ON 10* San Francisco +5.5 over Arizona, Sunday at 4:25 PM ET - Arizona has started the season a perfect 4-0 while San Fran is off back to back home losses vs Green Bay & Seattle. Thus, this line is higher than it should be according to our power ratings. If this was the season opener, we’re looking at right around pick-em for a line and now we get the Niners at +5. Arizona was very fortunate in their only home tilt this year as the Vikings missed a FG at the buzzer that would have given them the win (Zona won 34-33). They struggled to a 31-19 win @ Jacksonville but the Cards were trailing 19-10 late in the 3rd quarter in that game when a pick 6 turned the game around (Jax also had 4 TO’s). After picking up a nice win last week @ LA Rams (Rams were in letdown spot of win over Bucs) the Cardinals stock is a bit high right now. San Fran lost 28-21 at home to Seattle last week but they dominated the stat sheet with a +2.0 YPP differential, +1.1 YPC differential, and 9 more first downs. Starting QB Garoppolo was injured and rookie QB Lance came in an did very well in the 2nd half. While Lance was in the game the 49ers outgained Russell Wilson and the Seahawks 230 to 170 so he played well. It looks like he will most likely start this weekend which will be tough on Arizona with San Francisco bringing an entirely different offensive gameplan to the table that HC Shanahan has been waiting to unleash. The Cardinal defense will be running blind in this one as far as being able to game plan for the SF offense. The last 14 times San Francisco was coming off back to back losses as favorites, they were 11-3 ATS in their next game. This has been an underdog series with the puppy going 5-0-1 ATS the last 6 meetings including 4 outright wins. Last year the Niners were 6 point underdogs @ Arizona with CJ Beathard at QB and won the game! This is a buy low (SF) / sell high (Arizona) spot for us and we like the 49ers to get the cover.